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PUBLICATIONS

2022
  • Gualdrón-López M, Díaz-Varela M, Zanghi G, Aparici-Herraiz I, Steel RJW, Schäfer C, Cuscó P, Chuencho B, Kangwangransan N, Billman ZP, Olsen TM, González JR, Roobsoong W, Sattabongkot J, Murphy SC, Mikolajczak SA, Fernandez-Becerra C, Flannery EL, Kappe SHI and del Portillo HA. Identification of putative biomarkers of Plasmodium vivax hypnozoites in extracellular vesicles. Mol Cell Proteom (under revision)

  • Brito MAM, Baro B, Raiol TC, Ayllon-Hermida A, Safe IP, Deroost K, Figueiredo EFG, Costa AG, Armengol MDP, Sumoy L, Almeida ACG, Hounkpe BW, De Paula EV, Fernandez-Becerra C, Monteiro WM, Del Portillo HA, Lacerda MVG. Morphological and Transcriptional Changes in Human Bone Marrow During Natural Plasmodium vivax Malaria Infections. J Infect Dis. 2022 Apr 1;225(7):1274-1283. doi: 10.1093/infdis/jiaa177. PMID: 32556188; PMCID: PMC8974851.

  • Madeira RP, Meneghetti P, de Barros LA, de Cassia Buck P, Mady C, Ianni BM, Fernandez-Becerra C*, Torrecilhas AC*. Isolation and molecular characterization of circulating extracellular vesicles from blood of chronic Chagas disease patients. Cell Biol Int. 2022 Mar 7. doi: 10.1002/cbin.11787. Epub ahead of print. PMID: 35253308. *co-corresponding

  • Aparici Herraiz I, Caires HR, Castillo-Fernández Ó, Sima N, Méndez-Mora L, Risueño RM, Sattabongkot J, Roobsoong W, Hernández-Machado A, Fernandez-Becerra C, Barrias CC and del Portillo HA (2022) Advancing Key Gaps in the Knowledge of Plasmodium vivax Cryptic Infections Using Humanized Mouse Models and Organs-on-Chips. Front. Cell. Infect. Microbiol. 12:920204. doi: 10.3389/fcimb.2022.920204
2022
2021
  • Aparici-Herraiz I, Gualdrón-López M, Castro-CavadiaCJ , Carmona-Fonseca J, Yasnot MF, Fernandez-Becerra C, Del Portillo HA. Antigen discovery in circulating extracellular vesicles from Plasmodium vivax patients. 2022. Front. Cell. Infect. Microbiol. 11:811390. doi: 10.3389/fcimb.2021.811390

  • Fernandez-Becerra C, Aparici-Herraiz I, Del Portillo HA. Cryptic erythrocytic infections in Plasmodium vivax, another challenge to its elimination. Parasitol Int. 2021 Dec 9:102527. doi: 10.1016/j.parint.2021.102527. Epub ahead of print. PMID: 34896615.

  • Elizalde-Torrent A, Trejo-Soto C, Méndez-Mora L, Nicolau M, Ezama O, Gualdrón-López M, Fernández-Becerra C, Alarcón T, Hernández-Machado A, Del Portillo HA. Pitting of malaria parasites in microfluidic devices mimicking spleen interendothelial slits. Sci Rep. 2021 Nov 11;11(1):22099. doi: 10.1038/s41598-021-01568-w. PMID: 34764379; PMCID: PMC8585870.

  • Montaner-Tarbes S, Fraile L, Montoya M, Del Portillo H. Exosome-Based Vaccines: Pros and Cons in the World of Animal Health. Viruses. 2021 Jul 29;13(8):1499. doi: 10.3390/v13081499. PMID: 34452364; PMCID: PMC8402771.

  • Ketema T, Bacha K, Getahun K, Portillo HAD, Bassat Q. Plasmodium vivax epidemiology in Ethiopia 2000-2020: A systematic review and meta-analysis. PLoS Negl Trop Dis. 2021 Sep 15;15(9):e0009781. doi: 10.1371/journal.pntd.0009781. PMID: 34525091; PMCID: PMC8476039.

  • Kho S, Qotrunnada L, Leonardo L, Andries B, Wardani PAI, Fricot A, Henry B, Hardy D, Margyaningsih NI, Apriyanti D, Puspitasari AM, Prayoga P, Trianty L, Kenangalem E, Chretien F, Safeukui I, Del Portillo HA, Fernandez-Becerra C, Meibalan E, Marti M, Price RN, Woodberry T, Ndour PA, Russell BM, Yeo TW, Minigo G, Noviyanti R, Poespoprodjo JR, Siregar NC, Buffet PA, Anstey NM. Hidden Biomass of Intact Malaria Parasites in the Human Spleen. N Engl J Med. 2021 May 27;384(21):2067-2069. doi: 10.1056/NEJMc2023884. PMID: 34042394.

  • Kho S, Qotrunnada L, Leonardo L, Andries B, Wardani PAI, Fricot A, Henry B, Hardy D, Margyaningsih NI, Apriyanti D, Puspitasari AM, Prayoga P, Trianty L, Kenangalem E, Chretien F, Brousse V, Safeukui I, Del Portillo HA, Fernandez-Becerra C, Meibalan E, Marti M, Price RN, Woodberry T, Ndour PA, Russell BM, Yeo TW, Minigo G, Noviyanti R, Poespoprodjo JR, Siregar NC, Buffet PA, Anstey NM. Evaluation of splenic accumulation and colocalization of immature reticulocytes and Plasmodium vivax in asymptomatic malaria: A prospective human splenectomy study. PLoS Med. 2021 May 26;18(5):e1003632. doi: 10.1371/journal.pmed.1003632. PMID: 34038413; PMCID: PMC8154101.

  • Gualdrón-López M, Díaz-Varela M, Toda H, Aparici-Herraiz I, Pedró-Cos L, Lauzurica R, Lacerda MVG, Fernández-Sanmartín MA, Fernandez-Becerra C, Del Portillo HA. Multiparameter Flow Cytometry Analysis of the Human Spleen Applied to Studies of Plasma-Derived EVs From Plasmodium vivax Patients. Front Cell Infect Microbiol. 2021 Mar 1;11:596104. doi: 10.3389/fcimb.2021.596104. PMID: 33732657; PMCID: PMC7957050.(1)

  • Royo F, Azkargorta M, Lavin JL, Clos-Garcia M, Cortazar AR, Gonzalez-Lopez M, Barcena L, Del Portillo HA, Yáñez-Mó M, Marcilla A, Borras FE, Peinado H, Guerrero I, Váles-Gómez M, Cereijo U, Sardon T, Aransay AM, Elortza F, Falcon-Perez JM. Extracellular Vesicles From Liver Progenitor Cells Downregulates Fibroblast Metabolic Activity and Increase the Expression of Immune-Response Related Molecules. Front Cell Dev Biol. 2021 Jan 12;8:613583. doi: 10.3389/fcell.2020.613583. PMID: 33511119; PMCID: PMC7835421.

  • Monteiro EF, Fernandez-Becerra C, Curado I, Wunderlich G, Hiyane MI, Kirchgatter K. Antibody Profile Comparison against MSP1 Antigens of Multiple Plasmodium Species in Human Serum Samples from Two Different Brazilian Populations Using a Multiplex Serological Assay. Pathogens. 2021 Sep4;10(9):1138.

  • Monteiro EF, Fernandez-Becerra C, Araujo MDS, Messias MR, Ozaki LS, Duarte AMRC, Bueno MG, Catao-Dias JL, Chagas CRF, Mathias BDS, Santos MGD, Santos SV, Holcman MM, Jr JCS, Kirchgatter K. Naturally Acquired Humoral Immunity against Malaria Parasites in Non-Human Primates from the Brazilian Amazon, Cerrado and Atlantic Forest. Pathogens. 2020 Jun 29;9(7):525.
2021
2020
  • Monteiro W, Brito-Sousa JD, Elizalde-Torrent A, Bôtto-Menezes C, Melo GC, Fernandez-Becerra C, Lacerda M, Del Portillo HA. Cryptic Plasmodium chronic infections: was Maurizio Ascoli right? Malar J. 2020 Nov 30;19(1):440. doi: 10.1186/s12936-020-03516-x. PMID: 33256745; PMCID: PMC7708240.

  • Haruka Toda, Miriam Diaz-Varela, Joan Segui-Barber, Wanlapa Roobsoong, Barbara Baro, Susana Garcia-Silva, Alicia Galiano, Melisa Gualdrón-López, Anne CG Almeida, Marcelo AM Brito, Gisely Cardoso de Melo, Iris Aparici-Herraiz, Carlos Castro-Cavadía, Wuelton Marcelo Monteiro, Eva Borras, Eduard Sabido, Igor C. Almeida, Jakub Chojnacki, Javier Martinez-Picado, Maria Calvo, Pilar Armengol, Jaime Carmona-Fonseca, Maria Fernanda Yasnot, Ricardo Lauzurica, Antonio Marcilla, Hector Peinado, Mary R. Galinski, Marcus VG Lacerda, Jetsumon Sattabongkot, Carmen Fernandez-Becerra* and Hernando A del Portillo* (*equal correspondence). Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence. Nat Commun. 2020;11(1):2761. Published 2020 Jun 2. doi:10.1038/s41467-020-16337-y

  • Carmen Fernandez-Becerra*, Maria Bernabeu, Angélica Castellanos, Bruna R. Correa, Thomas Obadia, Miriam Ramirez, Edmilson Rui, Franziska Hentzschel, Maria López-Montañés, Alberto Ayllon-Hermida, Lorena Martin-Jaular, Aleix Elizalde-Torrent, Peter Siba, Ricardo Vencio, Myriam Arevalo-Herrera, Sócrates Herrera, Pedro L. Alonso, Ivo Mueller and Hernando A. del Portillo*. (*equal correspondence). Plasmodium vivax spleen-dependent genes encode antigens associated with cytoadhesion and clinical protection. Proc Natl Acad Sci U S A. 2020;117(23):13056-13065. doi:10.1073/pnas.1920596117

  • Marcelo A.M. Brito, Bàrbara Baro, Tainá C. Raiol, Alberto Ayllon-Hermida, Izabella P. Safe, Katrien Deroost, Erick F. G. Figueiredo, Allyson G. Costa, Maria del P. Armengol, Lauro Sumoy, Anne C.G. Almeida, Bidossessi W. Hounkpe, Erich V. De Paula, Cármen Fernandez-Becerra, Wuelton M. Monteiro, Hernando A. del Portillo* and Marcus V.G. Lacerda* (*equal correspondence). Morphological and Transcriptional Changes in Human Bone Marrow During Natural Plasmodium vivax Malaria Infections [published online ahead of print, 2020 Jun 18]. J Infect Dis. 2020;jiaa177. doi:10.1093/infdis/jiaa177

  • (2)LN, Kooijmans SAA, Chamorro LG, et al. Extracellular vesicles derived from Plasmodium-infected and non-infected red blood cells as targeted drug delivery vehicles [published online ahead of print, 2020 Jul 9]. Int J Pharm. 2020;587:119627. doi:10.1016/j.ijpharm.2020.119627

  • Llorà-Batlle O, Michel-Todó L, Witmer K, Toda H, Fernández-Becerra C, Baum J, Cortés A. Conditional expression of PfAP2-G for controlled massive sexual conversion in Plasmodium falciparum. Sci Adv. 2020 Jun 10;6(24): eaaz5057. IF= 13.117 (Q1 Multidisciplinary Sciences).

  • Cortes-Serra N, Losada-Galvan I, Pinazo MJ, Fernandez-Becerra C, Gascon J, Alonso-Padilla J. State-of-the-art in host-derived biomarkers of Chagas disease prognosis and early evaluation of anti-Trypanosoma cruzi treatment response. Biochim Biophys Acta Mol Basis Dis. 2020 Jul 1;1866(7):165758. IF= 4.352 (Q2 Molecular Biology).

  • Cortes-Serra N, Mendes MT, Mazagatos C, Segui-Barber J, Ellis CC, Ballart C, Garcia-Alvarez A, Gállego M, Gascon J, Almeida IC, Pinazo MJ*, Fernandez-Becerra C*. Plasma-Derived Extracellular Vesicles as Potential Biomarkers in Heart Transplant Patient with Chronic Chagas Disease. Emerg Infect Dis. 2020 Aug;26(8):1846-1851. *co-corresponding. IF= 6.259 (Q1 Infectious Diseases-- Sciences).
2020
2019
  • Tubita V, Segui-Barber J, Lozano JJ, Banon-Maneus E, Rovira J, Cucchiari D, Moya-Rull D, Oppenheimer F, Del Portillo H, Campisto(3)l JM, Diekmann F, Ramirez-BajoMJ, Revuelta I. Effect of immunosuppression in miRNAs from extracellular vesicles of colorectal cancer and their influence on the pre-metastatic niche. Sci Rep. 2019 Aug 1;9(1):11177

  • Montaner-Tarbes S, Del Portillo HA, Montoya M, Fraile L. Key gaps in the knowledge of the Procine Respiratory Reproductive Syndrome Virus (PRRSV). Front Vet Sci. 2019 Feb 20;6:38. doi: 10.3389/fvets.2019.00038. eCollection 2019. Review.
2019
2018
  • Théry C, Witwer K, Hill EF, Lotval J, Aikawa E, et al., Minimal Information for Studies of Extracellular Vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles, 7(1).

  • Montaner-Tarbes S, Novell E, Tarancón V, Borrás FE, Montoya M, Fraile L and del Portillo HA. Targeted-pig trial on safety and immunogenicity of serum-derived extracellular vesicle enriched fractions obtained from Porcine Respiratory and Reproductive virus infections. Sci Rep. 8:17487.

  • Díaz-Varela M, de Menezes-Neto A, Perez-Zsolt D, Gámez-Valero A, Seguí-Barber A, Izquierdo-Useros N, Martinez-Picado J, Fernández-Becerra C and del Portillo HA. Proteomics study of human cord blood reticulocyte-derived exosomes. Sci. Rep 2018, 8:14046.

  • Gualdrón-López M, Flannery EL, Kangwanrangsan N, Chuenchob V, Fernandez-Orth D, Segui-Barber J, Royo F, Falcón-Pérez JM, Fernandez-Becerra C, Lacerda MVG, Kappe SHI, Sattabongkot J, Gonzalez JR, Mikolajczak SA, and del Portillo HA. Discovery of Plasmodium vivax proteins in plasma-derived exosomes from malaria-infected liver-chimeric humanized mice. Front Microbiol. 2018 Jun 25;9:1271. doi: 10.3389/fmicb.2018.01271. eCollection 2018.

  • Elizalde-Torrent A, Val F, Azevedo ICC, Monteiro WM, Ferreira LCL, Fernández-Becerra C, Del Portillo HA, Lacerda MVG. Sudden spleen rupture in a Plasmodium vivax-infected patient undergoing malaria treatment. Malar J. 2018 Feb 13;17(1):79. doi: 10.1186/s12936-018-2228-2. PubMed PMID: 29433507; PubMed Central PMCID: PMC5809972.
2018
2017
  • Reiner AT, Witwer KW, van Balkom BWM, de Beer J, Brodie C, Corteling RL, Gabrielsson S, Gimona M, Ibrahim AG, de Kleijn D, Lai CP, Lötvall J, Del Portillo HA, Reischl IG, Riazifar M, Salomon C, Tahara H, Toh WS, Wauben MHM, Yang VK, Yang Y, Yeo RWY, Yin H, Giebel B, Rohde E, Lim SK. Concise Review: Developing Best-Practice Models for the Therapeutic Use of Extracellular Vesicles. Stem Cells Transl Med. 2017 Aug;6(8):1730-1739.

  • Martín-Jaular L, de Menezes-Neto A, Monguió-Tortajada M, Elizalde-Torrent A, Díaz-Varela M, Fernández-Becerra C, Borras FE, Montoya M, Del Portillo HA. Spleen-Dependent Immune Protection Elicited by CpG Adjuvanted Reticulocyte-Derived Exosomes from Malaria Infection Is Associated with Changes in T cell Subsets' Distribution. Front Cell Dev Biol. 2017 Jan 17;4:153.

  • Baro B, Deroost K, Raiol T, Brito M, Almeida AC, de Menezes-Neto A, Figueiredo EF, Alencar A, Leitão R, Val F, Monteiro W, Oliveira A, Armengol MD, Fernández-Becerra C, Lacerda MV, Del Portillo HA. Plasmodium vivax gametocytes in the bone marrow of an acute malaria patient and changes in the erythroid miRNA profile. PLoS Negl Trop Dis. 2017 Apr 6;11(4):e0005365.

  • Requena P, Rui E, Padilla N, Martínez-Espinosa FE, Castellanos ME, Bôtto-Menezes C, Malheiro A, Arévalo-Herrera M, Kochar S, Kochar SK, Kochar DK, Umbers AJ, Ome-Kaius M, Wangnapi R, Hans D, Menegon M, Mateo F, Sanz S, Desai M, Mayor A, Chitnis CC, Bardají A, Mueller I, Rogerson S, Severini C, Fernández-Becerra C, Menéndez C, Del Portillo H*, Dobaño C* (*equal correspondence). Plasmodium vivax VIR Proteins Are Targets of Naturally-Acquired Antibody and T Cell Immune Responses to Malaria in Pregnant Women. FPLoS Negl Trop Dis. 2016 Oct 6;10(10):e0005009.

  • De Niz M, Burda PC, Kaiser G, Del Portillo HA, Spielmann T, Frischknecht F, Heussler VT. Progress in imaging methods: insights gained into Plasmodium biology. Nat Rev Microbiol. 2017 Jan;15(1):37-54. doi: 10.1038/nrmicro.2016.158.

  • MalERA: An updated research agenda for basic science and enabling technologies in malaria elimination and eradication. The malERA Refresh Consultative Panel on Basic Science and Enabling Technologies. PLOS Medicine: 30 Nov 2017
2017